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Cocktail regimen in treatment of sudden sensorineural hearing loss

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Original Article

Author Details : Anusha Venkatraman*, Santosh Balasaheb Mane, Kamalika Purkayastha Roy, Poonam Khairnar

Volume : 7, Issue : 1, Year : 2024

Article Page : 7-11

https://doi.org/10.18231/j.ijoas.2024.003

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Abstract

Objective: This study aims to evaluate the efficacy of a cocktail regimen for the treatment of sudden sensorineural hearing loss (SSNHL).
Design: A prospective observational study.
Setting: Tertiary care hospital.
Participants: Thirty-five patients diagnosed with SSNHL who met the inclusion criteria.
Intervention: The cocktail regimen included intratympanic steroid injections, oral steroids, valacyclovir, and pentoxifylline.
Main Outcome Measures: The primary outcome was the change in Pure Tone Audiometry (PTA) from pre-treatment to 3 months post-treatment, analyzed by Modified Siegel’s criteria.
Results: Of the 35 patients, 26 (74.2%) showed hearing improvement (including complete and partial recovery) at the 3-month follow-up. The mean improvement in PTA was 22.56 dB (SD = 18.4). However, the calculated odds ratios (OR) for treatment efficacy and hearing recovery comparisons were 1.0, with wide confidence intervals, indicating no statistically significant differences between improved and not improved groups.
Conclusion: The cocktail regimen showed potential benefits for hearing recovery in SSNHL patients, particularly in cases with less severe initial hearing loss. Nevertheless, the absence of a statistically significant difference in the comparative analyses underscores the need for larger, randomized controlled trials to substantiate these findings.
 

Keywords: Sudden sensorineural hearing loss, Cocktail regimen, Hearing recovery

How to cite : Venkatraman A, Mane S B, Roy K P, Khairnar P, Cocktail regimen in treatment of sudden sensorineural hearing loss. J Otorhinolaryngol Allied Sci 2024;7(1):7-11

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