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Comparative Efficacy of intra-tympanic methylprednisolone injections in different concentrations on subjective cochlear tinnitus

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Original Article

Author Details : Manish Gupta*, Monica Gupta, Satish Kumar

Volume : 3, Issue : 3, Year : 2020

Article Page : 91-96

https://doi.org/10.18231/j.ijoas.2020.020

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Abstract

Introduction: Subjective tinnitus is an awareness of a phantom sound which is audible solely to the individual. Intra-tympanic steroid injections especially dexamethasone 8mg/ml have been used with variable success in relieving it; however this desired concentration is unavailable in India. The aim of this study was to assess the comparative efficacy of intra-tympanic methylprednisolone injections in different concentrations in subjective cochlear tinnitus.
Materials and Methods: Ninety patients with complaint of abnormal ringing in uni/bilateral ear, with/without hearing loss were enrolled from our outpatient set-up. After written informed consent, the participants received a tinnitus loudness and frequency matching test. They were randomly assigned into three different subgroups (each with 30 patients) by a single-blind method.0.5ml of 40mg/ml concentration methylprednisolone solution was injected intratympanically in study set one (Group A), 125mg/ml in
second set (Group B) and 250mg/ml in the third set (Group C). The groups were compared in terms of subjective tinnitus intensity and loudness matching after the intervention.
Results: On subjective analysis of tinnitus intensity 1 patient of Group A and 2 each of groups B and C demonstrated improvement. On loudness matching test for tinnitus, no patient in Group A was cured, though 3 each in groups B and C were cured.
Conclusions : In the present study, no significant change was observed in the three treatment groups in subjective analysis of tinnitus intensity based on questionnaire. Similarly a non-significant response was obtained in loudness matching test for tinnitus. The intra-tympanic methylprednisolone injection gave suboptimal and inconsistent results at varying concentrations. Further prospective studies to evaluate the effect of intratympanic methylprednisolone on tinnitus are warranted in carefully selected group of patients. 

Keywords: Tinnitus, IntraTympanic Perfusion Technique, Inner Ear, Treatment.

How to cite : Gupta M, Gupta M, Kumar S, Comparative Efficacy of intra-tympanic methylprednisolone injections in different concentrations on subjective cochlear tinnitus. J Otorhinolaryngol Allied Sci 2020;3(3):91-96

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